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Showing 1–3 of 3 results
Advanced filters: Author: "Zhu Chen" Clear advanced filters

  • A recent study in the New England Journal of Medicine reports the genomic and epigenomic changes in adult acute myeloid leukemia (AML). The patterns of somatic mutation suggest biologically relevant connections between the functional categories of genes driving AML.

    • Sai-Juan Chen
    • Yang Shen
    • Zhu Chen
    News & Views
    Nature Genetics
    Volume: 45, P: 586-587

  • This Review discusses the new data that have revealed surprising insights into the pathogenesis of acute promyelocytic leukaemia (APL) and the mechanism by which retinoic acid plus arsenic trioxide combination therapy targets the oncogenic fusion protein promyelocytic leukaemia (PML)–retinoic acid receptor-α (RARα), curing most cases of APL.

    • Hugues de Thé
    • Zhu Chen
    Reviews
    Nature Reviews Cancer
    Volume: 10, P: 775-783