An efficient and straightforward strategy for the synthesis of uniform, sequence-defined oligo(ester-amide-ester)s via sequential nucleophilic substitution reactions and Passerini reaction was developed. The side groups could be easily regulated by the Passerini reaction of different aldehydes. The synthesis of uniform, symmetrical, long-chain oligomers was further demonstrated by an iterative approach. The DIC/DPTS-mediated polycondensation of the α,ω-hydroxy carboxylic acids as the sequence-defined oligomer afforded high-molecular-weight periodic poly(ester-amide-ester)s. The thermal properties of these oligo/poly(ester-amide-ester)s were also examined.
- Yao-Zong Wang
- Jia-Chen Wang
- Zi-Chen Li
