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Showing 1–10 of 10 results

  • Improved understanding of kidney disease from a sex- and gender-specific perspective is needed to improve patient care. Here, the authors discuss differences in the epidemiology, management and outcomes of acute kidney injury, chronic kidney disease and kidney failure in men and women.

    • Nicholas C. Chesnaye
    • Juan Jesus Carrero
    • Kitty J. Jager
    Reviews
    Nature Reviews Nephrology
    Volume: 20, P: 7-20

  • Organ transplantation improves patient survival and quality of life and has a major beneficial impact on public health and the socio-economic burden of organ failure. This Roadmap presents an outline of the challenges to increasing transplantation rates and proposes 12 key areas along with specific measures that should be considered to promote transplantation.

    • Raymond Vanholder
    • Beatriz Domínguez-Gil
    • Gabriel C. Oniscu
    Reviews
    Nature Reviews Nephrology
    Volume: 17, P: 554-568

  • A growing body of research indicates that sex and gender-specific differences exist in the mechanisms and epidemiology of chronic kidney disease (CKD). Here, the authors describe current understanding of gender and sex differences in the epidemiology, treatment and outcomes of CKD, as well as the possible underlying causes.

    • Juan Jesus Carrero
    • Manfred Hecking
    • Kitty J. Jager
    Reviews
    Nature Reviews Nephrology
    Volume: 14, P: 151-164

  • Chronic kidney disease (CKD) is the progressive, irreversible loss of renal function that has many causes and contributing factors. In this Primer, the authors describe the many consequences of CKD and how understanding — and treating — the underlying cause can substantially slow CKD progression.

    • Paola Romagnani
    • Giuseppe Remuzzi
    • Hans-Joachim Anders
    Reviews
    Nature Reviews Disease Primers
    Volume: 3, P: 1-24

  • Chronic kidney disease (CKD) affects numerous organs and systems, which in turn have effects on kidney function. This Review provides an overview of CKD as a systemic disease and discusses the multidirectional links between the kidney, bone, nervous and immune systems, and metabolism.

    • Carmine Zoccali
    • Raymond Vanholder
    • Gerard London
    Reviews
    Nature Reviews Nephrology
    Volume: 13, P: 344-358

  • In many countries, patient outcomes with peritoneal dialysis are comparable or superior to those with haemodialysis. Here, the authors discuss the changing epidemiology of peritoneal dialysis worldwide, including the remaining country-specific challenges that must be overcome to improve utilization of this cost-effective therapy.

    • Philip Kam-Tao Li
    • Kai Ming Chow
    • Norbert Lameire
    Reviews
    Nature Reviews Nephrology
    Volume: 13, P: 90-103

  • Patients with chronic kidney disease (CKD) are known to have increased all-cause and cardiovascular mortality. Of late, it has been recognized that these patients also have increased noncardiovascular mortality. Here, the authors discuss both cardiovascular and nonocardiovascular mortality in CKD, provide examples of traditional cardiovascular risk factors that also seem to be associated with noncardiovascular mortality, and summarize the potential pathophysiological mechanisms involved.

    • Dinanda J. de Jager
    • Marc G. Vervloet
    • Friedo W. Dekker
    Reviews
    Nature Reviews Nephrology
    Volume: 10, P: 208-214

  • A new study by Chang et al. reports that coronary artery bypass grafting (CABG) may be preferable to percutaneous coronary intervention (PCI) for multivessel coronary revascularization in appropriately selected patients on maintenance dialysis.

    • Christoph Wanner
    • Kitty J. Jager
    News & Views
    Nature Reviews Nephrology
    Volume: 9, P: 197-198

  • One recent trial failed to show any beneficial effect of homocysteine lowering using vitamin B therapy on survival and cardiovascular events in patients with end-stage renal disease, and results of another study in patients with early-stage diabetic nephropathy actually suggested that vitamin B therapy has harmful effects. Do these findings mark the end of the era of studies investigating homocysteine lowering in patients with chronic kidney disease?

    • Carmine Zoccali
    • Kitty J. Jager
    News & Views
    Nature Reviews Nephrology
    Volume: 6, P: 695-696