Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.
Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results

  • DNA damage can cause mutations due to failure of DNA repair and errors during DNA replication. Tracking the strand of the DNA double helix on which damage occurs has shed light on processes that affect tumour evolution.

    • Trevor A. Graham
    • Sarah E. McClelland
    News & Views
    Nature
    Volume: 583, P: 207-209

  • Chromosomal abnormalities are a hallmark of many types of human cancer, but it has been difficult to observe such changes in living cells and to study how they arise. Progress is now being made on this front.

    • Sarah C. Johnson
    • Sarah E. McClelland
    News & Views
    Nature
    Volume: 570, P: 166-167

  • A mechanism to explain chromosomal instability (CIN) in colorectal cancer is demonstrated; three new CIN-suppressor genes (PIGN, MEX3C and ZNF516) encoded on chromosome 18q are identified, the loss of which leads to DNA replication stress, resulting in structural and numerical chromosome segregation errors, which are shown to be identical to phenotypes seen in CIN cells.

    • Rebecca A. Burrell
    • Sarah E. McClelland
    • Charles Swanton
    Research
    Nature
    Volume: 494, P: 492-496