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Showing 1–10 of 10 results
  • Neurons that regulate a mouse’s response to hunger and thirst also influence social interactions with the opposite sex.

    • Heidi Ledford
    News
    Nature
  • Hippocampal pyramidal cells encode an animal’s location by single action potentials and complex spike bursts. The authors show that Kcnq3-containing M-channels synergistically with GABAergic inputs coordinate complex spike bursts during theta oscillations, which is a key mechanism for spatial coding by single spikes.

    • Xiaojie Gao
    • Franziska Bender
    • Alexey Ponomarenko
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13
  • Food intake can be attenuated by visceral aversive stimuli in pathological conditions. Here the authors identify a unilateral neural circuit from the CamKII-positive neurons in the anterior insular cortex to the vGluT2-positive neurons in the lateral hypothalamus that controls feeding responses to visceral aversive stimuli.

    • Yu Wu
    • Changwan Chen
    • Shuang Qiu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • A neuronal population has now been found that regulates two competing needs — hunger and pain. Urgent pain overrides hunger, but appetite-inducing neuronal activity dampens long-term pain responses to enable feeding.

    • Alexey Ponomarenko
    • Tatiana Korotkova
    News & Views
    Nature
    Volume: 556, P: 445-446
  • Coordinated gamma oscillations in the lateral hypothalamus, lateral septum and medial prefrontal cortex are shown to drive food-seeking behaviour in mice independently of nutritional need and to organize firing of feeding behaviour-related hypothalamic neurons.

    • Marta Carus-Cadavieco
    • Maria Gorbati
    • Tatiana Korotkova
    Research
    Nature
    Volume: 542, P: 232-236
  • The authors identify a new arousal circuit in the mammalian brain. They provide correlative and optogenetic evidence indicating that a subset of hypothalamic cells drive awakening from non-rapid eye movement (slow-wave) sleep and emergence from anesthesia by exerting a strong inhibitory tone onto reticular thalamic neurons.

    • Carolina Gutierrez Herrera
    • Marta Carus Cadavieco
    • Antoine Adamantidis
    Research
    Nature Neuroscience
    Volume: 19, P: 290-298
  • Hippocampal theta oscillations support encoding of spatial information during navigation, yet their role in locomotion is poorly understood. Here the authors demonstrate that hippocampal theta oscillations regulate the speed of locomotion in rodents through a hippocampo-lateral septal-hypothalamic pathway.

    • Franziska Bender
    • Maria Gorbati
    • Alexey Ponomarenko
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11
  • Several K+ channels control neuronal excitability, but the function of KCNQ5 (Kv7.5), which displays wide expression in the brain, is not known. Here the authors show that KCNQ5 controls excitability and function of hippocampal networks through modulation of synaptic inhibition.

    • Pawel Fidzinski
    • Tatiana Korotkova
    • Thomas J. Jentsch
    Research
    Nature Communications
    Volume: 6, P: 1-13