Evolvability articles within Nature

Featured

• Article | 14 October 2020

  Dense and pleiotropic regulatory information in a developmental enhancer

  A robotic pipeline is used to survey a library of mutations in a Drosphila gene enhancer, showing that most mutations altered gene expression and had widespread pleiotropic effects that are likely to constrain regulatory evolution.

  • Timothy Fuqua
  • , Jeff Jordan
  •  & Justin Crocker

• Article | 06 November 2019

  An evolutionarily stable strategy to colonize spatially extended habitats

  To successfully colonize a habitat in the presence of competing chemotactic bacterial populations, the winner is required to expand its range at a speed given by the habitat size and the population doubling time.

  • Weirong Liu
  • , Jonas Cremer
  •  & Chenli Liu

• Letter | 30 May 2018

  Pairwise and higher-order genetic interactions during the evolution of a tRNA

  Mutagenesis of a yeast tRNA shows that the effects of mutations and how they interact varies both in magnitude and sign between genotypes.

  • Júlia Domingo
  • , Guillaume Diss
  •  & Ben Lehner

• Letter | 02 August 2017

  Proteins evolve on the edge of supramolecular self-assembly

  Introducing a single ‘sticky’ (hydrophobic) amino acid by point mutation into symmetric protein complexes frequently triggers their association into higher-order assemblies, without affecting their native fold and structure.

  • Hector Garcia-Seisdedos
  • , Charly Empereur-Mot
  •  & Emmanuel D. Levy