Featured
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Brief Communications Arising |
van Berlo et al. reply
- Jop H. van Berlo
- , Onur Kanisicak
- & Jeffery D. Molkentin
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Brief Communications Arising |
Kitcre knock-in mice fail to fate-map cardiac stem cells
- Carla Vicinanza
- , Iolanda Aquila
- & Daniele Torella
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Article |
Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
The secreted factor follistatin-like 1 (FSTL1) becomes undetectable in the epicardium of infarcted hearts; when reconstituted using a collagen patch sutured onto an infarcted heart, FSTL1 can induce cell cycle entry and division of pre-existing cardiomyocytes, thus boosting heart function and survival in mouse and pig models of myocardial infarction.
- Ke Wei
- , Vahid Serpooshan
- & Pilar Ruiz-Lozano
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Letter |
Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling
Using a genetic approach in zebrafish, the mesothelial covering of the heart—the epicardium—is shown to have a high regenerative ability after injury, a process that is driven by Hedgehog signalling originating from the outflow tract.
- Jinhu Wang
- , Jingli Cao
- & Kenneth D. Poss
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Article |
c-kit+ cells minimally contribute cardiomyocytes to the heart
Whether or not endogenous c-kit+cells residing within the heart contribute cardiomyocytes during physiological ageing or after injury remains unknown; here, using an inducible lineage tracing system, the c-kit+lineage is shown to generate cardiomyocytes at very low levels, and, by contrast, contributes substantially to cardiac endothelial cell generation.
- Jop H. van Berlo
- , Onur Kanisicak
- & Jeffery D. Molkentin
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News |
Heart cells coaxed to divide and conquer
The heart does have a limited ability to heal itself — and a genetic 'trick' can harness this.
- Kerri Smith
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Letter |
Mammalian heart renewal by pre-existing cardiomyocytes
During normal ageing a low rate of division of pre-existing cardiomyocytes, rather than progenitor cells, is responsible for cardiomyocyte genesis; this process is increased fourfold during myocardial infarction.
- Samuel E. Senyo
- , Matthew L. Steinhauser
- & Richard T. Lee
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Research Highlights |
Stem cells from the heart
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News |
Stem cells patch up 'broken' heart
Cell reactivation in mouse hearts repairs muscle after heart attack.
- Marian Turner
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Letter |
De novo cardiomyocytes from within the activated adult heart after injury
- Nicola Smart
- , Sveva Bollini
- & Paul R. Riley
An acute immune response underlies the benefit of cardiac stem cell therapy