Histocytochemistry articles within Nature Communications

Featured

• Article
  27 September 2023 | Open Access

  Social isolation shortens lifespan through oxidative stress in ants

  The mechanisms behind the negative effects of social isolation on social species are unclear. Here, the authors examine colonies of carpenter ants, finding that behavioral, physiological, and lifespan changes may be caused by oxidative stress.

  • Akiko Koto
  • , Makoto Tamura
  •  & Laurent Keller

• Article
  21 June 2022 | Open Access

  Cyclic microchip assay for measurement of hundreds of functional proteins in single neurons

  Current single-cell tools are limited by the number of proteins they can analyse. Here the authors report a single-cell cyclic multiplex in situ tagging (CycMIST) method for functional proteome profiling of single cells, allowing multiple rounds of multiplexing of the same single cells on a microchip.

  • Liwei Yang
  • , Avery Ball
  •  & Jun Wang

• Article
  13 May 2022 | Open Access

  Phase separation and zinc-induced transition modulate synaptic distribution and association of autism-linked CTTNBP2 and SHANK3

  Autism impacts synapses. This study reports that autism-linked mutations of CTTNBP2 regulate phase separation to control synaptic enrichment of that protein. A zinc-induced liquid-to-gel transition improves synaptic retention of CTTNBP2 and SHANK3.

  • Pu-Yun Shih
  • , Yu-Lun Fang
  •  & Yi-Ping Hsueh

• Article
  24 August 2020 | Open Access

  Tissue sodium excess is not hypertonic and reflects extracellular volume expansion

  Na⁺ has been suggested to accumulate in tissues, particularly skin, in a hypertonic manner and to exert local pathogenic effects. Here, we reappraise this phenomenon which is systemic in nature and reflects isotonic changes in the relative extracellular volume in tissues, e.g. subclinical oedema; as such, it occurs in human hypertension and aging.

  • Giacomo Rossitto
  • , Sheon Mary
  •  & Christian Delles

• Article
  11 September 2019 | Open Access

  In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene

  Although many neuropsychiatric risk genes are known to contribute to epigenetic regulation of gene expression, very little is known about specific chromatin-associated mechanisms that govern the formation and maintenance of neuronal connectivity. Here, the authors report that transcallosal connectivity is critically dependent on C11orf46/ARL14EP, a nuclear protein encoded in the chromosome 11p13 WAGR risk locus, and that RNA-guided epigenetic editing of hyperexpressed Sema6a gene promoters in C11orf46-knockdown neurons resulted in normalization of expression and rescue of transcallosal dysconnectivity via repressive chromatin remodeling.

  • Cyril J. Peter
  • , Atsushi Saito
  •  & Atsushi Kamiya