Neurological models articles within Nature Communications

Featured

• Article
  29 March 2024 | Open Access

  Projective light-sheet microscopy with flexible parameter selection

  Projection imaging for multi-cellular samples can be hindered by several factors, including low contrast. Here, the authors propose projective light-sheet imaging with parameter selection (props) of imaging depth, position and viewing angle.

  • Bingying Chen
  • , Bo-Jui Chang
  •  & Reto Fiolka

• Article
  19 July 2023 | Open Access

  Spatially controlled construction of assembloids using bioprinting

  Bioprinting has potential in the biofabrication of three dimensional tissues, but is poorly suited to the manipulation of neural organoids. Here, the authors develop a bioprinting platform to allow the arrangement of organoids to form assembloids.

  • Julien G. Roth
  • , Lucia G. Brunel
  •  & Sarah C. Heilshorn

• Article
  19 October 2022 | Open Access

  HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids

  Complex neuropathologies, like macular degeneration, are common but incompletely understood. Here the authors report a complex human retina pathology organoid model induced by HBEGF-TNF, causing PIEZO1-mediated photoreceptor degeneration by cell extrusion.

  • Manuela Völkner
  • , Felix Wagner
  •  & Mike O. Karl

• Article
  29 July 2022 | Open Access

  Functional neuronal circuitry and oscillatory dynamics in human brain organoids

  Brain organoids replicate cellular organization found in the developing human brain. Here, the authors utilize microelectronics to map activity in brain organoids and assemble functional circuits that mirror complexity found in brain networks in vivo.

  • Tal Sharf
  • , Tjitse van der Molen
  •  & Kenneth S. Kosik

• Article
  30 June 2021 | Open Access

  SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome

  Schinzel-Giedion syndrome (SGS) is a fatal developmental syndrome characterized by severe intellectual and physical deficits due, at least in part, to early neurodegeneration. Here the authors introduce a human SGS model that displays disease-relevant phenotypes to demonstrate that neuronal death in SGS originates from developmental alterations mainly in safeguarding cell identity and homeostasis.

  • Federica Banfi
  • , Alicia Rubio
  •  & Alessandro Sessa

• Article
  13 March 2020 | Open Access

  Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

  The relationship between amyloid-β species and tau pathology in Alzheimer’s disease is not fully understood. Here, the authors show that it is the increased ratio of amyloid-β42 and 40 isoforms drives tau pathology in 3D human neural cell culture models of the disease.

  • Sang Su Kwak
  • , Kevin J. Washicosky
  •  & Doo Yeon Kim

• Article
  02 April 2019 | Open Access

  Cortex-wide neural interfacing via transparent polymer skulls

  Imaging the mouse brain using glass cranial windows has limitations in terms of flexibility and long-term imaging. Here the authors engineer transparent polymer skulls that can fit various skull morphologies and can be implanted for over 300 days, enabling simultaneous high resolution brain imaging and electrophysiology across large cortical areas.

  • Leila Ghanbari
  • , Russell E. Carter
  •  & Suhasa B. Kodandaramaiah