The microbiome is known to affect antitumor immune responses, but how this occurs is unclear. Rhamnose-rich polysaccharides (RHP) from a commensal strain of Lactiplantibacillus plantarum have now been shown to induce iron sequestration by tumor macrophages, thereby limiting tumor growth and promoting antitumor immunity.
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E.E. declares that they are a scientific founder of Daytwo and BiomX and a paid consultant to PurposeBio, Aposense and Zoe on topics unrelated to this piece.
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Nobs, S.P., Elinav, E. A microbial iron fist to fight tumors. Nat Immunol 25, 720–721 (2024). https://doi.org/10.1038/s41590-024-01806-z
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DOI: https://doi.org/10.1038/s41590-024-01806-z