Abstract
A STUDY of the O-methylation of wool and silk with methyl bromide and methyl sulphate showed the extent of methylation could not be entirely accounted for as esterification of free carboxyl groups and we suggested that methylation of activated peptide linkages also took place1. We have now obtained evidence suggesting the activated peptide linkages are possibly those which have undergone condensation with the side-chains of Î-hydroxy acids, for example, serine and threonine. By this condensation, oxazoline rings may arise, which Bergmann and Miekeley2, from studies of the reactions of O- and N-benzoylserine, have considered possible constituents of proteins.
Similar content being viewed by others
Article PDF
References
Blackburn, S., Carter, E. G. H., and Phillips, H., Biochem. J., 35, 627 (1941).
Bergmann, M., and Miekeley, A., Z. Physiol. Chem., 140, 128 (1924).
Linderstrom-Lang, K., and Jacobsen, C. F., J. Biol. Chem., 137, 443 (1941).
Patterson, W. I., Geiger, W. B., Mizell, L. R., and Harris, M., J. Res. Nat. Bur. Stand., Wash., 27, 29 (1941).
Middlebrook, W. R., and Phillips, H., Biochem. J. (in press).
Hopkins, F. G., NATURE, 126, 328, 383 (1930).
Mirsky, A. E., J. Gen. Physiol., 19, 559 (1936).
Greenstein, J. P., J. Biol. Chem., 125, 501 (1938).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BLACKBURN, S., MIDDLEBROOK, W. & PHILLIPS, H. Oxazoline and Thiazoline Rings in Proteins. Nature 150, 57 (1942). https://doi.org/10.1038/150057a0
Issue Date:
DOI: https://doi.org/10.1038/150057a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.