Abstract
A NUMBER of papers have appeared recently dealing with di-isopropylfluorophosphonate, which was prepared by McCombie and Saunders1 in 1941 and found by Adrian, Feldberg and Kilby2 to cause a prolonged inhibition of cholinesterase. One of us (J. H. G.) tested its effect on myasthenia gravis in 1943, but had to abandon the work owing to lack of clinical material. This work was continued by the other, and the object of this letter is to report the results.
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References
McCombie, H., and Saunders, B. C., Nature, 157, 287 (1946).
Adrian, E. D., Feldberg, W., and Kilby, B. A., Nature, 158, 625 (1946).
Comroe, J. H., Todd, J., Gammon, C. D., Leopold, I. H., Koelle, G. B., Bodansky, O., and Gilman A., Amer. J. Med. Sci., 212, 641 (1946).
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GADDUM, J., WILSON, A. Treatment of Myasthenia gravis with Di-isopropylfluorophosphonate. Nature 159, 680–681 (1947). https://doi.org/10.1038/159680b0
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DOI: https://doi.org/10.1038/159680b0
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