Abstract
ONE of the steps of the biosynthesis of guanylic acid from adenylic acid involves the diphosphopyridine nucleotide-linked dehydrogenation of inosinic acid to xanthylic acid1â3: inosinic acid+diphosphopyridine nueleotide+ â xanthylic acid + reduced diphosphopyridine nucleotide. When this reaction was studied with chicken-liver enzyme extracts by following the appearance of the absorption peak at 340 mµ characteristic of reduced diphosphopyridine nucleotide, a strong reduction of the coenzyme was observed not only in the presence of inosinic acid but also with the corresponding purine base hypoxanthine.
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FELLIG, J., WILEY, C. Enzymatic Dehydrogenation of Hydroxypurines and Hydroxypteridines. Nature 181, 51â52 (1958). https://doi.org/10.1038/181051a0
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DOI: https://doi.org/10.1038/181051a0
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