Abstract
OBSERVATIONS on the action of cobalt compounds on living organisms revealed that this is to some extent similar to that of histamine. Therefore, as mast cells may produce and/or store histamine and histamine-like substances attached to heparin molecules, it was of interest to see if the cells examined were influenced by cobalt compounds. These were given intraperitoneally to white mice in a single dose of 100 mgm. cobalt/kgm. body-weight, in the form of cobalt nitrate, acetate and chloride. Another series of mice received 5 mgm. cobalt/kgm. in the same salts daily for 3 weeks. Specimens of the skin were fixed and stained by a modified Nowak and Zahl stain1.
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References
Nowak, D., and Zahl, W., Stain Technol., 24, 180 (1949).
Riley, J. F., Science, 118, 332 (1953).
Fawcett, W., J. Exp. Med., 100, 217 (1954).
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NIEBROJ, T. Mast Cells. Nature 181, 991 (1958). https://doi.org/10.1038/181991a0
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DOI: https://doi.org/10.1038/181991a0
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