Abstract
BOTH anoxia and pretreatment with certain thiols will reduce the sensitivity to radiation of many types of living organisms. The possibility that thiols protect against radiation damage because they lower oxygen tension has been reviewed by Gray1 and by Pihl and Eldjarn2. In spite of all the work done it is not yet clear whether the protective thiols act by inducing tissue anoxia or by some other means.
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References
Gray, L. H., “Ann. Rev. Nuclear Sci.”, 6, 353 (1956).
Pihl, A., and Eldjarn, L., Pharmacol. Rev., 10, 437 (1958).
Pirie, A., and Lajtha, L. G., Nature, 184, 1125 (1959).
von Sallmann, L., Amer. Med. Assoc. Arch. Ophthal., 47, 305 (1952).
Howard, A., Stain Technol., 27, 313 (1952).
von Sallmann, L., Dische, Z., Ehrlich, G., and Munoz. C. M., Amer. J. Ophthal., 34, May, Pt. 2, 95 (1951).
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PIRIE, A., VAN HEYNINGEN, R. Comparison between the Effects of Cysteine and of Anoxia on the Rate of Mitosis in Lens Epithelium. Nature 187, 947–948 (1960). https://doi.org/10.1038/187947a0
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DOI: https://doi.org/10.1038/187947a0
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