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Development of Delayed-type Hypersensitivity in Guinea Pig Embryos

Nature volume 187, pages 957–959 (1960)Cite this article

Abstract

SEVERAL, modalities of the immune response of embryos have been previously investigated. These include : (a) induction of immunological tolerance1; (b) antibody formation2; (c) capacity to reject homografts3. There have been no analogous studies of the capacity of the embryo to develop the delayed type of hypersensitivity to protein antigens.

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References

  1. Billingham, R. E., Brent, L., and Medawar, P. B., Nature, 172, 603 (1953).

    Article  ADS  CAS  Google Scholar 

  2. Fennestad, K. L., and Borg-Peterson, C., Nature, 180, 1210 (1957). Sterzl, J., Kostka, J., Riha, I., and Mandel, L., Folia Microbiologica, 5, 29 (1960).

    Article  ADS  CAS  Google Scholar 

  3. Schinkel, P. G., and Ferguson, K. A., Austral. J. Biol. Sci., 6, 533 (1953).

    Article  Google Scholar 

  4. Freund, J., J. Immunol., 13, 285 (1927).

    Google Scholar 

  5. Waksman, B. H., and Matoltsy, M., J. Immunol., 81, 235 (1958).

    CAS  Google Scholar 

  6. Weiss, D. W., J. Exp. Med., 108, 83 (1958).

    Article  CAS  Google Scholar 

  7. Uhr, J. W., Salvin, S., and Pappenheimer, jun., A. M., J. Exp. Med., 105, 11 (1957).

    Article  Google Scholar 

  8. Gell, P. G. H., and Hinde, I. T., Brit. J. Exp. Path., 32, 516 (1951).

    CAS  PubMed  Google Scholar 

  9. Ibsen, H. L., J. Exp. Zool., 51, 51 (1928). Draper, R. L., Anat. Rec., 18, 369 (1920).

    Article  Google Scholar 

  10. Freund, J., J. Immunol., 17, 465 (1929).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Departments of Microbiology and Medicine, New York University School of Medicine, New York

    JONATHAN W. UHR

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  1. JONATHAN W. UHR
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UHR, J. Development of Delayed-type Hypersensitivity in Guinea Pig Embryos. Nature 187, 957–959 (1960). https://doi.org/10.1038/187957b0

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