Abstract
POOLE1 reported in 1955 that when certain fatty acids in low concentration are added to plasma the clotting time is shortened. In 1959 he2 modified Chandler's3 system to make and to study artificial thrombi. In 1961, with Connor4, he showed that when straight-chain saturated fatty acids with 16 or more carbon atoms were added to mixtures of blood in Chandler's system thrombus formation was accelerated and the thrombi so formed larger. Short -chain fatty acids, C6 and C7, had no activity and unsat-urated acids were inactive, or very nearly so.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Poole, J. C. F., Brit. J. Exp. Path., 36, 248 (1955).
Poole, J. C. F., Quart. J. Exp. Physiol., 44, 377 (1959).
Chandler, A. B., Lab. Invest., 7, 110 (1958).
Connor, W. G., and Poole, J. C. F., Quart. J. Exp. Phys., 46, 1 (1961).
Connor, W. G., Hoak, J. C., and Warner, E. D., Fed. Proc., 21, 60 (1962) (abstract).
Soloff, L. A., and Day, H. J., Clin. Proc. (to be published) (abstract).
Nicoll, P. A., and Webb, R. L., Ann. N.Y. Acad. Sci., 46, 697 (1946).
Duguid, J. B., J. Path. Bact., 58, 207 (1946).
Anitschow, N., Chalatow, S., Centrablf. allg. Path. Path. Anat., 24, 1 (1913).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SOLOFF, L., WIEDEMAN, M. Biomicroscopic Observations on Vasocon-strictive and Thrombogenic Effects produced by Long-chain Saturated Fatty Acids within the Vasculature of the Wing of an Unanæsthetized Bat. Nature 199, 495–496 (1963). https://doi.org/10.1038/199495a0
Issue Date:
DOI: https://doi.org/10.1038/199495a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.