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Behavioural Effects of in utero Administration of Morphine

Nature volume 247, pages 376–377 (1974)Cite this article

Abstract

ALTHOUGH numerous studies have been concerned with the behavioural effects of opiates, relatively little attention has been paid to the offspring of females receiving an opiate during pregnancy. The matured offspring's response to stress and to the same drug are important issues in terms of current drug abuse and potential widespread application of opiate maintenance programmes. Since morphine is readily transferred across both placental and lacteal barriers1,2, we have studied the analgesic response to morphine in the offspring of mice receiving the drug during gestation and lactation.

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References

  1. Shute, E., and Davis, E., Surg. Gynec. Obst., 57, 727 (1933).

    Google Scholar 

  2. Blane, G. F., and Dobbs, H. E., Br. J. Pharmac., 30, 167 (1967).

    Google Scholar 

  3. Glick, S. D., Greenstein, S., and Goldfarb, J., Behav. Biol. (in the press).

  4. Davis, J. D., and Miller, N. E., Science, N.Y., 141, 1286 (1963).

    Article  ADS  CAS  Google Scholar 

  5. Cochin, J., and Kornetsky, C., J. pharm. exp. Ther., 145, 1 (1964).

    CAS  Google Scholar 

  6. Johannesson, T., and Milthers, K., Acta pharmacol Toxicol., 19, 241 (1962).

    Article  CAS  Google Scholar 

  7. Wikler, A., and Pescor, F. T., Psychopharmacologia, 10, 255 (1967).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pharmacology, Mount Sinai School of Medicine, Fifth Avenue and 100th Street, New York, New York, 10029

    B. ZIMMERBERG, A. D. CHARAP & S. D. GLICK

  2. H. M. Singer Laboratory of Neurosciences and Addictive Diseases, Beth Israel Medical Center, 307 Second Avenue, New York, New York, 10003

    B. ZIMMERBERG, A. D. CHARAP & S. D. GLICK

Authors
  1. B. ZIMMERBERG
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  2. A. D. CHARAP
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  3. S. D. GLICK
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ZIMMERBERG, B., CHARAP, A. & GLICK, S. Behavioural Effects of in utero Administration of Morphine. Nature 247, 376–377 (1974). https://doi.org/10.1038/247376a0

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