Abstract
THE human papilloma (wart) virus produces a transmissible, benign neoplastic disease which is self-limiting and often regresses. Although rare, papillomas containing papovavirus-like particles may undergo malignant transformation. Papillomas in epidermodysplasia verruciformis and condyloma acuminatum can become neoplastic1–4. Reports of the wart virus replicating in or transforming cells in culture, however, have not been substantiated5–7. Butel was unable to demonstrate cytopathic effect, the production of viral antigens or virus replication using a variety of cell lines and culture techniques8. Mild stimulation of cellular DNA synthesis, however, was observed in contact-inhibited embryonic human kidney cells after infection8. We also have been able to induce cellular DNA synthesis in confluent monolayers of a cell line derived from foetal human foreskin (NHP cells) following infection by wart virus.
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LANCASTER, W., MEINKE, W. Persistence of viral DNA in human cell cultures infected with human papilloma virus. Nature 256, 434–436 (1975). https://doi.org/10.1038/256434a0
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DOI: https://doi.org/10.1038/256434a0
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