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Activation of HIV gene expression during monocyte differentiation by induction of NF-kB

Nature volume 339, pages 70–73 (1989)Cite this article

Abstract

THE latent period of AIDS is influenced by factors which activate human immunodeficiency virus (HIV) replication in different cell types. Although monocytic cells may provide a reservoir for virus production in vivo1–8, their regulation of HIV transcription has not been defined. We now report that HIV gene expression in the monocyte lineage is regulated by NF-kB, the same transcription factor known to stimulate the HIV enhancer in activated T cells9; however, control of NF-kB and HIV in monocytes differs from that observed in T cells. NF-kB-binding activity appears during the transition from promonocyte to monocyte in U937 cells induced to differentiate in vitro and is present constitutively in mature monocytes and macrophages. In a chronically infected pro-monocytic cell, Ul, differentiation is associated with HIV-1 replication as well as NF-kB binding activity. These findings suggest that NF-kB binding activity is developmentally regulated in the monocyte lineage, and that it provides one signal for HIV activation in these cells.

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Author information

Author notes

  1. Gary J. Nabel: To whom correspondence should be addressed.

Authors and Affiliations

  1. Howard Hughes Medical Institute, Departments of Internal Medicine and Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, 48109, USA

    George E. Griffin, Kwanyee Leung & Gary J. Nabel

  2. Retrovirus Diseases Branch, Centers for Disease Control, Atlanta, Georgia, 30333, USA

    Thomas M. Folks

  3. Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA

    Steven Kunkel

  4. Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA

    George E. Griffin

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  1. George E. Griffin
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  2. Kwanyee Leung
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  3. Thomas M. Folks
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  4. Steven Kunkel
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  5. Gary J. Nabel
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Griffin, G., Leung, K., Folks, T. et al. Activation of HIV gene expression during monocyte differentiation by induction of NF-kB. Nature 339, 70–73 (1989). https://doi.org/10.1038/339070a0

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