Abstract
T CELLS that recognize self antigen are clonally deleted in the thymus—a maturation process that occurs in the context of histo-compatibility molecules and the T-cell receptor. The minor lymphocyte stimulation antigens (Mis) effect these deletions through interactions with the Vβ portion of the T-cell receptor, thus mimicking bacterial 'superantigens'. Intrigued by the fact that each known Mls gene maps to the same chromosomal region as an endogenous mouse mammary tumour virus (Mtv), we re-evaluated the linkage relationships between the two gene families. Here we report perfect concordance in inbred and recombinant inbred mice between the presence of four Mtv proviruses with the expression of Mls gene products. These data suggest a general model in which mammary tumour virus gene products themselves are the ligands that shape a considerable portion of the immuno-logical repertoire of common laboratory mice.
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References
Festenstein, H., Bishop, C. & Taylor, B. A. Immunogenetics 5, 357 (1977).
Traina, V. L., Taylor, B. A. & Cohen, J. C. J. Virol. 40, 735–744 (1981).
MacInnes, J. I., Morris, V. L., Flintoff, W. F. & Kozak, C. A. Virology 132, 12–25 (1984).
Michalides, R., Verstraeten, R., Shen, F. W. & Hilgers, J. Virology 142, 278–290 (1985).
Abe, R., Ryan, J. J. & Hodes, R. J. exp. Med. 165, 1113 (1987).
Kozak, C. et al. J. Virol. 61, 1651–1654 (1987).
Seldin, M. F., Abe, R., Steinber, A. D., Hodes, R. J. & Morse, H. C. J. Immunogenet. 15, 59 (1988).
Lee, B. K. & Eicher, E. M. J. Virol. 64, 4568–4572 (1990).
Eicher, E. M. & Lee, B. K. Genetics 125, 431–446 (1990).
Abromson-Leeman, S. R., Laning, J. C. & Dorf, M. E. J. Immun. 140, 1726 (1988).
Ryan, J. J., LeJeune, H. B., Mond, J. J. & Finkelman, F. D. J. Immun. 144, 2506 (1990).
Silver, J. J. Hered. 78, 436–440 (1985).
Pullen, A. M., Marrack, P. & Kappler, J. W. Nature 335, 796–801 (1988).
Pullen, A. M., Marrack, P. & Kappler, J. W. J. Immun. 142, 3033–3037 (1989).
Frankel, W. N., Stoye, J. P., Taylor, B. A. & Coffin, J. M. Genetics 124, 221–236 (1990).
Cho, M., Villani, V. & D'Eustachio, P. Mamm. Genome (in the press).
Woodland, D., Happ, M. P., Bill, J. & Palmer, E. Science 247, 964–967 (1990).
King, L. B., Lund, F. E., White, D. A., Sharma, S. & Corley, R. J. Immun. 144, 3218–3227 (1990).
Abe, R., Foo-Philips, M. & Hodes, R. J. Immunogenetics (in the press).
Pauley, R. J., Parks, W. P. & Popko, B. J. Virus Res. 1, 381–400 (1984).
Aziz, D. C., Hanna, Z. & Jolicoeur, P. Nature 338, 505–508 (1989).
Chattopadhyay, S. K., Morse, H. C. I., Makino, M., Ruscetti, S. K. & Hartley, J. W. Proc. natn. Acad. Sci. U.S.A. 86, 3862–3866 (1989).
Morse, H. C., Yetter, R. A., Via, C. S. et al. J. Immun. 143, 844–850 (1989).
Li, J. P., D'Andrea, A. D., Lodish, H. F. & Baltimore, D. Nature 343, 762–764 (1990).
Yoshimura, A., D'Andrea, A. D. & Lodish, H. F. Proc. natn. Acad. Sci. U.S.A. 87, 4139–4143 (1990).
Marrack, P., Kushnir, E. & Kappler, J. Nature 349, 524–526 (1991).
Michalides, R. E. et al. J. Virol. 43, 819–829 (1982).
Dudley, J. & Risser, R. J. Virol. 49, 92–101 (1984).
Ball, J. K., Arthur, L. O. & Dekaban, G. A. Virology 140, 159–172 (1985).
Kappler, J. W. et al. Cold Spring Harb. Symp. quant. Biol. 54, 401–408 (1989).
Marrack, P. C. & Kappler, J. W. Science 248, 705–711 (1990).
Janeway, C. A. Cell 63, 659–661 (1990).
Morse, H. in The Mouse in Biomedical Research (Academic, New York, 1981).
Seldin, M. F., Morse, H. C., LeBoeuf, R. C. & Steinberg, A. D. Genomics 2, 48–56 (1988).
Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning: A Laboratory Manual. (Cold Spring Harbor Laboratory, New York, 1982).
Gray, D. A., Chan, E. C. M. L., MacInnes, J. I. & Morris, V. L. Virology 148, 237–242 (1986).
Majors, J. E. & Varmus, H. E. Nature 289, 253–258 (1981).
Peters, G., et al. J. Virol. 59, 535–544 (1986).
Majors, J. E. & Varmus, H. E. J. Virol. 47, 495–504 (1983).
Prochazka, M. & Leiter, E. H. Mouse Genome 87, 111 (1990).
Stoye, J. P. & Coffin, J. M. in RNA Tumor Viruses (eds Weiss, N. T., Varmus, H. E. and Coffin, J. M.) 357–404 (Cold Spring Harbor, New York, 1985).
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Frankel, W., Rudy, C., Coffin, J. et al. Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice. Nature 349, 526–528 (1991). https://doi.org/10.1038/349526a0
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DOI: https://doi.org/10.1038/349526a0
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