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Synaptic mechanism in Alzheimer’s disease: a selective degeneration of an excitatory synaptic pathway in the CA1 hippocampus that controls spatial learning and memory in Alzheimer’s disease

Molecular Psychiatry volume 23, page 167 (2018)Cite this article

Excitatory pyramidal neurons in the entorhinal cortical layer II region (ECIIPN) directly innervate parvalbumin neurons in the CA1 hippocampus (CA1PV). (a) A brain section from ChR2 loxP/loxP mice injected with 1.2 μl of the AAV1/2-D28K-Cre virus particles in the ECII region and stained with DAPI. (b) High magnification of a selected area shows the ChR2-eGFP expression in ECIIPN. (c) Whole-cell patch clamp recordings from ECIIPN in a slice from the ECIIPNChR2+ mouse. Representative recordings of action potential firings in ECIIPN in response to blue laser light illuminations in ECIIPN. (d) The evoked EPSCs in CA1PV in response to the increased intensities of blue laser lights in the slices from a ECIIPNChR2+ mouse. For more information on this topic, please refer to the article by Yang et al. on pages 199–210.

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Authors and Affiliations

  1. Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    X Yang, C Yao, T Tian, X Li, H Yan, J Wu, H Li & Y Lu

  2. The Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China

    X Yang, C Yao, T Tian, X Li, H Yan, J Wu, H Li, L Pei, D Liu, Q Tian, L-Q Zhu & Y Lu

  3. Department of Neurobiology, Tongji School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China

    L Pei

  4. Department of Genetics, Tongji School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China

    D Liu

  5. Department of Pathophysiology, Tongji School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China

    Q Tian & L-Q Zhu

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Yang, X., Yao, C., Tian, T. et al. Synaptic mechanism in Alzheimer’s disease: a selective degeneration of an excitatory synaptic pathway in the CA1 hippocampus that controls spatial learning and memory in Alzheimer’s disease. Mol Psychiatry 23, 167 (2018). https://doi.org/10.1038/mp.2018.1

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