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Structural biology

Enzyme target to latch on to

Nature volume 443, pages 761–762 (2006)Cite this article

Insulin-degrading enzyme is implicated in diabetes and Alzheimer's disease, but few molecular tools exist that can probe its function. A study now reveals its unusual structure and may lead to an expanded toolbox.

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Figure 1: Enzyme activation.

Notes

  1. *This article and the paper concerned1 were published online on 11 October 2006.

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Authors and Affiliations

  1. Department of Biochemistry, Scripps Florida, The Scripps Research Institute, Jupiter, 33458, Florida, USA

    Malcolm A. Leissring

  2. Center for Neurologic Diseases, Brigham & Women's Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Dennis J. Selkoe

Authors
  1. Malcolm A. Leissring
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  2. Dennis J. Selkoe
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Leissring, M., Selkoe, D. Enzyme target to latch on to. Nature 443, 761–762 (2006). https://doi.org/10.1038/nature05210

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