Abstract
Arising from: P. Puigserver et al. Nature 423, 550–555 (2003).
Increased expression of the gene encoding the enzyme glucose-6-phosphatase (G6Pase) contributes to the increased production of glucose by the liver that occurs in individuals with diabetes. Puigserver et al.1 show that the transcription factor FOXO1 and the transcriptional co-activator PGC-1α act synergistically to stimulate the expression of genes in the gluconeogenesis pathway and propose that PGC-1α acts, in part, directly through FOXO1. Here we show that FOXO1 is neither required nor sufficient for the stimulation of G6Pase–luciferase fusion gene expression by PGC-1α. Our results indicate that the transcriptional interaction between FOXO1 and PGC-1α is indirect.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Puigserver, P. et al. Nature 423, 550–555 (2003).
Finck, B. N. & Kelly, D. P. J. Clin. Invest. 116, 615–622 (2006).
Lin, J., Handschin, C. & Spiegelman, B. M. Cell Metab. 1, 361–370 (2005).
Boustead, J. N. et al. Biochem. J. 369, 17–22 (2003).
Vander Kooi, B. T. et al. Mol. Endocrinol. 19, 3001–3022 (2005).
Vander Kooi, B. T. et al. J. Biol. Chem. 278, 11782–11793 (2003).
Rhee, J. et al. Proc. Natl Acad. Sci. USA 100, 4012–4017 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schilling, M., Oeser, J., Boustead, J. et al. Re-evaluating the FOXO1–PGC-1α connection. Nature 443, E10–E11 (2006). https://doi.org/10.1038/nature05288
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature05288
This article is cited by
-
Novel regulation of renal gluconeogenesis by Atp6ap2 in response to high fat diet via PGC1-α/AKT-1 pathway
Scientific Reports (2021)
-
FOXO transcription factor family in cancer and metastasis
Cancer and Metastasis Reviews (2020)
-
Reduced risk of apoptosis: mechanisms of stress responses
Apoptosis (2017)
-
Epigenetic regulation of caloric restriction in aging
BMC Medicine (2011)
-
Could Sirt1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions?
AGE (2009)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.