To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt — a major kinase that coordinates diverse signalling pathways — phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphorylation activates SCF-Skp2 through multiple mechanisms.
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Ecker, K., Hengst, L. Skp2: caught in the Akt. Nat Cell Biol 11, 377–379 (2009). https://doi.org/10.1038/ncb0409-377
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DOI: https://doi.org/10.1038/ncb0409-377
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