Senescence, a cell-autonomous tumour suppressor mechanism, also has pro-tumorigenic effects on neighbouring pre-malignant cells through the senescence-associated secretory phenotype (SASP). The SASP is now shown to be regulated by inflammasomes and to induce paracrine senescence in healthy cells, indicating that senescence may also represent a non-cell-autonomous tumour suppressor mechanism linked to innate immunity.
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Hoare, M., Narita, M. Transmitting senescence to the cell neighbourhood. Nat Cell Biol 15, 887–889 (2013). https://doi.org/10.1038/ncb2811
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DOI: https://doi.org/10.1038/ncb2811
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