Using the protein of interest as a template, weakly binding ligands can be chemically linked to produce protein-binding agents that can compete with nature's own.
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Kodadek, T. Antibody surrogates click into place. Nature Chem 1, 183–185 (2009). https://doi.org/10.1038/nchem.228
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DOI: https://doi.org/10.1038/nchem.228