Antibiotics can break down through the action of enzymes or through non-enzymatic processes. In the case of tetracycline, this drug 'debris' can have unexpected biological activities, including selection against resistance.
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Wright, G. Inactive but not inert. Nat Chem Biol 6, 85–86 (2010). https://doi.org/10.1038/nchembio.299
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DOI: https://doi.org/10.1038/nchembio.299