The podocyte is a highly specialized kidney cell that is essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein. Four studies, the most recent of which is published in this issue of Nature Genetics, indicate its critical role in the pathology of nephrotic syndrome.
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References
Boute, N. Nature Genet 24, 349–354 (2000).
Kestila, M. et al. Mol. Cell 1, 575–582 (1998).
Shih, N.Y. et al. Science 286, 312–315 (1999).
Kaplan, J.M. et al. Nature Genet. 24, 251– 256 (2000).
Rodewald, R. & Karnovsky, M.J. J. Cell Biol. 60 , 423–433 (1974).
Smoyer, W.E. & Mundel, P. J. Mol. Med. 76, 172–183 (1998).
Kriz, W., Gretz, N. & Lemley, K.V. Kidney Int. 54, 687– 697 (1998).
Ruotsalainen, V. et al. Proc. Natl Acad. Sci. USA 96, 7962– 7967 (1999).
Smoyer, W.E., Mundel, P., Gupta, A. & Welsh, M.J. Am. J. Physiol. 273, 150–157 ( 1997).
Fuchshuber, A. et al. Hum. Mol. Genet. 4, 2155– 2158 (1995).
Huang, M., Gu, G., Ferguson, E.L. & Chalfie, M. Nature 378, 292–295 (1995).
Winn, M.P. et al. Genetics 58, 113–120 (1999).
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Somlo, S., Mundel, P. Getting a foothold in nephrotic syndrome. Nat Genet 24, 333–335 (2000). https://doi.org/10.1038/74139
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DOI: https://doi.org/10.1038/74139
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