Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Getting a foothold in nephrotic syndrome

The podocyte is a highly specialized kidney cell that is essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein. Four studies, the most recent of which is published in this issue of Nature Genetics, indicate its critical role in the pathology of nephrotic syndrome.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The structure of the glomerulus.
Figure 2: Glomerular ultrastructure.
Figure 3: Molecular anatomy of the podocyte foot process cytoskeleton.

References

  1. Boute, N. Nature Genet 24, 349–354 (2000).

    Article  CAS  Google Scholar 

  2. Kestila, M. et al. Mol. Cell 1, 575–582 (1998).

    Article  CAS  Google Scholar 

  3. Shih, N.Y. et al. Science 286, 312–315 (1999).

    Article  CAS  Google Scholar 

  4. Kaplan, J.M. et al. Nature Genet. 24, 251– 256 (2000).

    Article  CAS  Google Scholar 

  5. Rodewald, R. & Karnovsky, M.J. J. Cell Biol. 60 , 423–433 (1974).

    Article  CAS  Google Scholar 

  6. Smoyer, W.E. & Mundel, P. J. Mol. Med. 76, 172–183 (1998).

    Article  CAS  Google Scholar 

  7. Kriz, W., Gretz, N. & Lemley, K.V. Kidney Int. 54, 687– 697 (1998).

    Article  CAS  Google Scholar 

  8. Ruotsalainen, V. et al. Proc. Natl Acad. Sci. USA 96, 7962– 7967 (1999).

    Article  CAS  Google Scholar 

  9. Smoyer, W.E., Mundel, P., Gupta, A. & Welsh, M.J. Am. J. Physiol. 273, 150–157 ( 1997).

    Google Scholar 

  10. Fuchshuber, A. et al. Hum. Mol. Genet. 4, 2155– 2158 (1995).

    Article  CAS  Google Scholar 

  11. Huang, M., Gu, G., Ferguson, E.L. & Chalfie, M. Nature 378, 292–295 (1995).

    Article  CAS  Google Scholar 

  12. Winn, M.P. et al. Genetics 58, 113–120 (1999).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Somlo, S., Mundel, P. Getting a foothold in nephrotic syndrome. Nat Genet 24, 333–335 (2000). https://doi.org/10.1038/74139

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/74139

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing