The antiviral factor APOBEC3G upregulates the expression of ligands for the activating receptor NKG2D via DNA damage induced by the viral protein Vpr in cells infected with human immunodeficiency virus. The virus overcomes greater susceptibility to natural killer cell–mediated lysis by targeting APOBEC3G for degradation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Altfeld, M., Fadda, L., Frleta, D. & Bhardwaj, N. Nat. Rev. Immunol. 11, 176–186 (2011).
Norman, J.M. et al. Nat. Immunol. 12, 975–983 (2011).
Planelles, V. & Barker, E. Mol. Aspects Med. 31, 398–406 (2010).
Cerboni, C. et al. J. Gen. Virol. 88, 242–250 (2007).
Chiu, Y.-L. & Greene, W.C. Annu. Rev. Immunol. 26, 317–353 (2008).
Ramiro, A.R. et al. Nature 440, 105–109 (2006).
Gasser, S., Orsulic, S., Brown, E.J. & Raulet, D.H. Nature 436, 1186–1190 (2005).
Langevin, C. et al. J. Virol. 83, 10256–10263 (2009).
Harris, R.S. Nat. Biotechnol. 26, 1089–1090 (2008).
Mulder, L.C.F., Harari, A. & Simon, V. Proc. Natl. Acad. Sci. USA 105, 5501–5506 (2008).
Nolting, A. et al. Virology 406, 12–20 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Croxford, J., Gasser, S. Damage control: how HIV survives the editor APOBEC3G. Nat Immunol 12, 925–927 (2011). https://doi.org/10.1038/ni.2115
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.2115