Persistence is a poorly understood yet widespread outcome of viral infection. A study of RNA viruses in flies now shows that viral fragments endogenized as cDNA during the reverse transcription of retrotransposons provide immunity based on RNA-mediated interference in persistently infected cells.
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References
Goic, B. et al. Nat. Immunol. 14, 396–403 (2013).
Boldogh, I. Albrecht, T. & Porter, D. in Medical Microbiology 4th edn. (ed. Baron, S.) Ch. 46 (The University of Texas Medical Branch at Galveston, 1996).
Voinnet, O. Nat. Rev. Genet. 6, 206–220 (2005).
Li, H., Li, W.X. & Ding, S.W. Science 296, 1319–1321 (2002).
Geuking, M.B. et al. Science 323, 393–396 (2009).
Klenerman, P., Hengartner, H. & Zinkernagel, R.M. Nature 390, 298–301 (1997).
Wessler, S.R. Curr. Biol. 6, 959–961 (1996).
Dunoyer, P. et al. Science 328, 912–916 (2010).
Saleh, M.C. et al. Nature 458, 346–350 (2009).
Wingard, S.A. J. Agric. Res. 37, 127–153 (1928).
Ratcliff, F., Harrison, B.D. & Baulcombe, D.C. Science 276, 1558–1560 (1997).
Wu, Q. et al. Proc. Natl. Acad. Sci. USA 107, 1606–1611 (2010)
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Voinnet, O. How to become your own worst enemy. Nat Immunol 14, 315–317 (2013). https://doi.org/10.1038/ni.2571
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DOI: https://doi.org/10.1038/ni.2571