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Erythropoiesis lagging? pIgA1 steps in to assist Epo

Nature Medicine volume 17, pages 1346–1348 (2011)Cite this article

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Although erythropoietin (Epo) is commonly used as a therapy for anemia, recent studies have suggested that Epo therapy is associated with adverse outcomes. A new study shows that polymeric IgA1 positively regulates erythropoiesis through binding to transferrin receptor 1 (Tfr1), suggesting new therapeutic routes for anemia (pages 1456–1465).

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Figure 1: pIgA1 and Fe-Tf bind TfR1 to stimulate Epo-dependent erythroblast proliferation and development.

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  1. Department of Veterinary and Biomedical Sciences. The Pennsylvania State University, Robert F. Paulson is at the Center for Molecular Immunology and Infectious Disease, University Park, Pennsylvania, USA.,

    Robert F Paulson

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  1. Robert F Paulson
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Correspondence to Robert F Paulson.

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Paulson, R. Erythropoiesis lagging? pIgA1 steps in to assist Epo. Nat Med 17, 1346–1348 (2011). https://doi.org/10.1038/nm.2501

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