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Malondialdehyde (MDA) is a lipid peroxidation product, the amounts of which are increased in several chronic inflammatory diseases. The authors now show that complement factor H binds MDA and can block macrophage uptake of MDA-modified proteins and MDA-mediated inflammation in mice.
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Swami, M. Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nat Med 17, 1357 (2011). https://doi.org/10.1038/nm.2566
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DOI: https://doi.org/10.1038/nm.2566
