This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Disease specific characteristics of fetal epigenetic markers for non-invasive prenatal testing of trisomy 21
BMC Medical Genomics Open Access 08 January 2014
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Papageorgiou, E.A. et al. Nat. Med. 17, 510–513 (2011).
Papageorgiou, E.A. et al. Am. J. Pathol. 174, 1609–1618 (2009).
Bianchi, D.W. et al. Am. J. Hum. Genet. 61, 822–829 (1997).
Lo, Y.M.D. et al. Am. J. Hum. Genet. 62, 768–775 (1998).
Tong, Y.K. et al. Clin. Chem. 56, 90–98 (2010).
Lun, F.M.F. et al. Clin. Chem. 54, 1664–1672 (2008).
Hamada, H., Arinami, T., Kubo, T., Hamaguchi, H. & Iwasaki, H. Hum. Genet. 91, 427–432 (1993).
Bianchi, D.W. et al. Prenat. Diagn. 22, 609–615 (2002).
Zweig, M.H. & Campbell, G. Clin. Chem. 39, 561–577 (1993).
Acknowledgements
This project was supported by the University Grants Committee of the Government of the Hong Kong Special Administration Region, China—Areas of Excellence Scheme (AoE/M-04/06). We thank A. Cheng, S. Lau, L. Lu and P. Jiang for helpful discussions.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
All authors hold or have filed patent applications on aspects of noninvasive prenatal diagnosis. Part of this patent portfolio has been licensed to Sequenom. Y.M.D.L. and R.W.K.C. are consultants to, hold equities in, and receive research support from Sequenom.
Supplementary information
Supplementary Text and Figures
Supplementary Tables 1–4, Supplementary Figure 1 and Supplementary Methods (PDF 294 kb)
Rights and permissions
About this article
Cite this article
Tong, Y., Chiu, R., Chan, K. et al. Technical concerns about immunoprecipitation of methylated fetal DNA for noninvasive trisomy 21 diagnosis. Nat Med 18, 1327–1328 (2012). https://doi.org/10.1038/nm.2915
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.2915