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Of telomeres and tumors

The enzyme, telomerase, may be switched on in tumor cells. Inhibitors of this enzyme might constitute a new class of anti-cancer drugs.

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References

  1. deLange, T. Telomere dynamics and genome instability. in Telomeres (eds Blackburn, E.H. & Greider, C.W.) 265–293 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1995).

    Google Scholar 

  2. Counter C.M. et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921–1929 (1992).

    Article  CAS  Google Scholar 

  3. Harley, C.B., Futcher, A.B. & Greider, C.W. Telomeres shorten during ageing of human fibroblasts. Nature 345, 458–460 (1990).

    Article  CAS  Google Scholar 

  4. Blasco, M.A., Rizen, M., Greider, C.W. & Hanahan, D. Differential regulation of telomerase activity and telomerase RNA during multistage tumorigenesis. Nature Genet. 12, 1–5 (1996).

    Article  Google Scholar 

  5. Chong, L. et al. A human telomeric protein. Science 270, 1663–1667 (1995).

    Article  CAS  Google Scholar 

  6. Harley, C.B. Telomeres and aging. in Telomeres (eds Blackburn, E. H. & Greider, C.W.) 247–263 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1995).

    Google Scholar 

  7. Kim, N.W. et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011–2014 (1994).

    Article  CAS  Google Scholar 

  8. Feng, J. et al. The RNA component of human telomerase. Science 269, 1236–1241 (1995).

    Article  CAS  Google Scholar 

  9. Counter, C.M., Hirte, H.W., Bacchetti, S. & Harley, C.B. Telomerase activity inhuman ovarian carcinoma. Proc. Natl. Acad. Sci. USA 91, 2900–2904 (1994).

    Article  CAS  Google Scholar 

  10. Hiyama, E. et al. Correlating telomerase activity levels with human neuroblastoma outcomes. Nature Med. 1, 249–255 (1995).

    Article  CAS  Google Scholar 

  11. Blasco, M., Funk, W.B. & Greider, C.W. Functional characterization and developmental regulation of mouse telomerase RNA. Science 269, 1267–1270 (1995).

    Article  CAS  Google Scholar 

  12. Broccoli, D., Young, J. & deLange, T. . Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. USA 92, 9082–9086 (1995).

    Article  CAS  Google Scholar 

  13. Lundblad, V. & Blackburn, E.H. An alternative pathway for yeast telomere maintenance rescues est1 senescence. Cell 73, 347–360 (1993).

    Article  CAS  Google Scholar 

  14. Biessmann, H. et al. HeT-A, a transposable element specifically involved in “healing” broken chromosome ends in Drosophila. Mol. Cell. Biol. 12, 3910–3918 (1992).

    Article  CAS  Google Scholar 

  15. Bryan, T.M., Englezou, A., Gupta, J., Bacchetti, S. & Reddel, R.R. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14, 4240–4248 (1995).

    Article  CAS  Google Scholar 

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Axelrod, N. Of telomeres and tumors. Nat Med 2, 158–159 (1996). https://doi.org/10.1038/nm0296-158

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