Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Making antisense of pain

Nature Neuroscience volume 16, pages 986–987 (2013)Cite this article

Subjects

A study now identifies a long noncoding antisense RNA that contributes to neuropathic pain through the suppression of potassium channel expression.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Kcna2 antisense RNA is upregulated following peripheral nerve injury.

References

  1. Jan, L.Y. & Jan, Y.N. J. Physiol. (Lond.) 590, 2591–2599 (2012).

    Article  CAS  Google Scholar 

  2. Everill, B. & Kocsis, J.D. J. Neurophysiol. 82, 700–708 (1999).

    Article  CAS  PubMed  Google Scholar 

  3. Ishikawa, K., Tanaka, M., Black, J.A. & Waxman, S.G. Muscle Nerve 22, 502–507 (1999).

    Article  CAS  PubMed  Google Scholar 

  4. Zhao, X. et al. Nat. Neurosci. 16, 1024–1031 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Basbaum, A.I., Bautista, D.M., Scherrer, G. & Julius, D. Cell 139, 267–284 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Guttman, M. et al. Nature 458, 223–227 (2009).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Ponting, C.P., Oliver, P.L. & Reik, W. Cell 136, 629–641 (2009).

    Article  CAS  PubMed  Google Scholar 

  8. Wapinski, O. & Chang, H.Y. Trends Cell Biol. 21, 354–361 (2011).

    Article  CAS  PubMed  Google Scholar 

  9. Rinn, J.L. & Chang, H.Y. Annu. Rev. Biochem. 81, 145–166 (2012).

    Article  CAS  PubMed  Google Scholar 

  10. Woolf, C.J. et al. J. Comp. Neurol. 360, 121–134 (1995).

    Article  CAS  PubMed  Google Scholar 

  11. Bao, L. et al. Eur. J. Neurosci. 16, 175–185 (2002).

    Article  PubMed  Google Scholar 

  12. Shendure, J. & Church, G.M. Genome Biol. 3, RESEARCH0044 (2002).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Rasband, M.N. et al. Proc. Natl. Acad. Sci. USA 98, 13373–13378 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Physiology, Tina W. Han and Lily Yeh Jan are in the Howard Hughes Medical Institute, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.,

    Tina W Han & Lily Yeh Jan

Authors
  1. Tina W Han
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lily Yeh Jan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lily Yeh Jan.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Han, T., Jan, L. Making antisense of pain. Nat Neurosci 16, 986–987 (2013). https://doi.org/10.1038/nn.3475

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3475

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing