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The C-terminus of p53: the more you learn the less you know

Nature Structural Biology volume 8, pages 730–732 (2001)Cite this article

NMR analyses of variants of the p53 tumor suppressor protein that either contain or lack the C-terminus reveal that the C-terminus neither interacts with other regions of p53 nor has an impact on the conformation of the rest of the molecule. Nevertheless, the C-terminus is likely to be critical for regulation of p53 function.

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Figure 1: Domain organization and tumor-derived mutations of the tumor suppressor protein p53.
Figure 2: Different theories as to how the C-terminus of p53 regulates sequence-specific DNA binding by the central core domain.

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  1. the Department of Biological Sciences, Columbia University, New York, 10027, New York, USA

    Jinwoo Ahn & Carol Prives

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  1. Jinwoo Ahn
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Correspondence to Carol Prives.

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Ahn, J., Prives, C. The C-terminus of p53: the more you learn the less you know. Nat Struct Mol Biol 8, 730–732 (2001). https://doi.org/10.1038/nsb0901-730

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