The bacterial pathogen Staphylococcus aureus secretes a high-affinity insulin-binding protein that mediates insulin resistance, a major driver of obesity and type 2 diabetes, in a mouse model of infection.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Haeusler, R. A., McGraw, T. E. & Accili, D. Nat. Rev. Mol. Cell Biol. 19, 31–44 (2017).
Olsen, K. et al. PLoS ONE 8, e63716 (2013).
Smit, J. et al. Eur. J. Endocrinol. 174, 631–639 (2016).
Vu, B. G. et al. mBio 6, e02554 (2015).
Kahn, S. E., Hull, R. L. & Utzschneider, K. M. Nature 444, 840–846 (2006).
Liu, Y. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0146-2 (2018).
Donath, M. Y. & Shoelson, S. E. Nat. Rev. Immunol. 11, 98–107 (2011).
Spaulding, A. R. et al. Clin. Microbiol. Rev. 26, 422–47 (2013).
Hanses, F., Roux, C., Dunman, P. M., Salzberger, B. & Lee, J. C. Genome Med. 6, 93 (2014).
Schlievert, P. M., Salgado-Pabón, W. & Klingelhutz, A. J. Future Microbiol. 10, 1549–1552 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Weidenmaier, C. Staphylococcus aureus blocks insulin function. Nat Microbiol 3, 533–534 (2018). https://doi.org/10.1038/s41564-018-0153-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41564-018-0153-3