The role of cell adhesion molecules (CAMs) in oligodendrocyte–axon contact and myelination is not well understood. Overexpression of the membrane-bound extracellular domain of the CAM CADM4 (CADM4-ED) in cultured oligodendrocytes resulted in an increased number of axoglial contact sites but reduced myelin maturation compared with controls. Overexpression of CADM4-ED in mice resulted in hypomyelination of axons and inappropriate myelination of soma. These results indicate a key role for axoglial CAMs in proper myelin targeting and maturation.
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Elazar, N. et al. Axoglial adhesion by Cadm4 regulates CNS myelination. Neuron https://doi.org/10.1016/j.neuron.2018.11.032 (2018)
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Lewis, S. All wrapped up. Nat Rev Neurosci 20, 69 (2019). https://doi.org/10.1038/s41583-018-0117-x
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DOI: https://doi.org/10.1038/s41583-018-0117-x