A comprehensive genetic screen reveals new cellular trafficking factors and linker-dependent requirements for antibody–drug conjugate (ADC) cytotoxicity. These new insights may guide the design of optimized ADCs.
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The authors are employees of Seattle Genetics, a company engaged in the field of antibody–drug conjugates.
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Van Epps, H.A., Senter, P.D. Breaking up is hard to do. Nat Chem Biol 15, 934–935 (2019). https://doi.org/10.1038/s41589-019-0351-1
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DOI: https://doi.org/10.1038/s41589-019-0351-1