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Pseudotyping messenger RNA-packaging virus-like particles with a glycoprotein recognizing a surface protein on dendritic cells led to higher humoral and adaptive immune responses in mice.
Transthoracic ultrasound localization microscopy enables super-resolution imaging of myocardial microvasculature and haemodynamics in patients with impaired myocardial function using data acquired within a breath hold.
Durable and robust lymph-node expansion is associated with the efficacy of therapeutic vaccination, as shown in mice immunized via a biomaterial-based vaccine.
Intramyocardial injection of synthetic mRNA coding for the embryonic T-box transcription factor 18 gene generates rate-adaptive cardiac pacing and limits innate and inflammatory immune responses, as shown in rodents and pigs.
The removal of terminal sialic acid residues on glycans at the T-cell–tumour-cell interface via a sialidase fused to a bispecific T-cell engager enhances the susceptibility of solid cancers to T-cell-mediated cytolysis.
The hydrophobicity, electrostatic charge and secondary conformation of helical polypeptides can be optimized to stimulate antitumour innate immune responses via endoplasmic reticulum stress in antigen-presenting cells.
The densities of blood vessels and of tumour-associated macrophages are key predictive features of the degree of accumulation of polymeric and liposomal nanomedicines, as shown for specimens of mouse and human tumours.
The esterification of butyrate to serine makes for an odourless and tasteless oral prodrug that ameliorated disease severity and reduced inflammatory responses in mouse models of rheumatoid arthritis and multiple sclerosis.
Antigen-specific immunosuppression can be enhanced by genetically modifying mesenchymal stromal cells with chimaeric antigen receptors, as shown for the treatment of graft-versus-host disease in mice.
Intratumourally administered bacteria coated with manganese dioxide modulate the immunosuppressive tumour microenvironment and potently activate antitumour immune responses, as shown in multiple solid tumours in small animals.
Blocking the mechanical sensor PIEZO1 in cytotoxic T lymphocytes strengthens their traction forces and augments their cytotoxicity against tumour cells.
Cascaded diffusion models can be used to synthesize realistic whole-slide image tiles from latent representations of RNA-sequencing data from human tumours.
Wireless miniaturized implantable temperature sensors enable real-time monitoring of the progression of inflammatory bowel diseases, as shown in a mouse model of Crohn’s-disease-like ileitis.
The development of dental calculi involves bacteria in local mature biofilms converting the DNA in neutrophil extracellular traps from being degradable by the enzyme DNase I to being degradation resistant.
Mouse B cells can be reprogrammed via Cas12a to express human antibodies that when affinity-matured in recipient mice generate broader and more potent antibody variants.
Hydronium ions bordering cancer cells are highly concentrated into a small extracellular region, and in tumour tissue such severely polarized acidity correlates with the expression of monocarboxylate transporters and with the exclusion of cytotoxic T cells.
The intravenous injection of neutrophils bearing discoidal polymer microscale ‘patches’ on their surfaces reduces tumour burden in mice owing to the patch-induced polarization of the neutrophils towards an antitumour phenotype.
A machine-learning model trained on interactions between oral drugs and intestinal drug transporters obtained by modulating their expression in intact porcine tissue can be used to predict drug–transporter and drug–drug interactions.
The off-tumour toxicity of a supramolecular bispecific T cell engager can be halted by disengaging T cells from the tumour cells via the disassembly of the supramolecular aggregate through the infusion of the small-molecule drug amantadine.
The delivery of mRNAs into neurons at inflammatory sites in vivo can be enhanced by engineering leucocytes to produce extracellular vesicles incorporating mRNA-packaging retrovirus-like capsids.