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Many cyclic dipeptide natural products can be modified by cyclodipeptide oxidase enzymes. Here, the authors report the structural characterization of the cyclodipeptide oxidase AlbAB and show that it assembles into heterooligomeric enzyme filaments.
Fragile X syndrome is a neurodevelopmental disorder with altered neuronal excitability and behavior. Here, the authors show that dysfunction of astroglial Kir4.1 potassium channels drives neuronal and behavioral impairments in a fragile X mouse model.
The authors present a 3D determination of the ferroelectric domain structure in a hexagonal yttrium manganite nanocrystal using multi-peak Bragg coherent x-ray diffraction imaging and reconstructing the full displacement field and strain tensor
Single-cell RNA sequencing data analysis is limited by noise and high dimensionality. Here, authors present scLENS, a tool that automates accurate signal detection without manual input, particularly in complex datasets.
Initially anode-free batteries with garnet-type solid-state electrolytes suffer from internal strain by repeated Li plating/stripping. Here, the authors propose a near-strain-free anode architecture for interfacial diffusion of Li metal that suppresses volume expansion during cycling.
In most materials, the hall conductivity has a scaling to the longitudinal resistance that varies between linear and quadratic. Here, Zhang et al demonstrate a hall conductivity proportional to the fifth power of the longitudinal conductivity in Mn3Si2Te6, which they attribute to enhanced force on charge carriers due to chiral orbital currents.
MCM8-9 and HROB function together in DNA damage response. Here, the authors describe the mechanism of DNA unwinding by MCM8-9 and its activation by HROB. HROB makes direct contacts with both MCM8 and MCM9 and promotes DNA unwinding downstream of MCM8-9 loading and hexameric ring formation on DNA.
Paralog synthetic lethals have been assessed with multiple CRISPR-based methods, but systematic comparison among these platforms is unavailable. Here, the authors systematically compare combinatorial perturbation platforms and establish the in4mer CRISPR/Cas12a multiplex knockout platform.
The work proposes the concept of distinct micro-habitats within an intact soil matrix and describes composition and metabolic pathways of their bacterial inhabitants, as a first step towards a generalizable C processing-focused classification of soil micro-environmental conditions.
A major challenge for spin-based information technologies is the generation of spin polarization in otherwise nonmagnetic materials. Here, Arnoldi et al. demonstrate how ultrafast laser excitations can be used to generate spin polarization in a fullerene/tungsten diselenide heterostructure.
Graphene oxide is a promising material for molecular separation technologies. Here, the authors propose a realistic staggered stacking structure that plays a crucial role in H/D recognition in water adsorption, as well as high mobilities of water.
Cancer stem cells (CSCs) are associated with chemoresistance and poor prognosis in multiple cancer types. Here, the authors investigate the role of secreted Wnt ligands in pancreatic and breast CSCs and identify E2F1/4-GCN5-pRb/RBL2 as a regulatory axis underlying Wnt secretion.
A stimulus-responsive approach for recapitulating nonviral nucleocapsid assembly on demand under controlled conditions provides a robust platform for applications in synthetic biology and mRNA nanomedicine.
NEDD8 is a ubiquitin-like protein that governs protein neddylation, previously demonstrated to be essential for cell survival. Here the authors show that NEDD8 loss in breast cancer cells is associated with enhanced immunogenicity and increased sensitivity to PD-1 blockade in preclinical cancer models.
Magnetostatic wave filters have a wide working frequency range, small size and high Q-factor, however, they are hampered by the need for a large external electromagnet to provide a bias magnetic field. Here, Du et al demonstrate an extremely small and low power external magnetic bias assembly with zero static power consumption, removing the need for bulky and energy intensive electromagnets.