Table 1 Characteristics of the patients

From: Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling

Variable

Patients without cholestasis

Patients with cholestasis

p valuea

Patients (n)

26

20

0.25

Short bowel syndrome (n)

6

9

0.59

Male (n)

16

11

0.69

Age (months)

5 (3.3–6)

5 (3.1–7)

0.87

Gestational age (weeks)

37 (31.5–38)

36 (30–39)

0.58

Gestational weight (g)

2900 (1486–3162)

2650 (2030–3025)

0.08

Plasma alkaline phosphatase, ALP (U/L)

240.5 (201.5–286.5)

275 (173–311.6)

<0.01

Plasma alanine aminotransferase, ALT (U/L)

45 (31.5–89)

56 (33.6–97)

<0.01

Plasma aspartate aminotransferase, AST (U/L)

59 (47.9–98.7)

67 (56.5–114.5)

<0.01

Plasma total bilirubin (μmol/L)

9.7 (9.2–18.5)

13.5 (9.5–34.2)

0.01

Plasma conjugated bilirubin (μmol/L)

2.3 (0.2–5.2)

10.5 (9.3–22.5)

0.03

Serum IL-6 (pg/mL)

4.2 (4.6–7.8)

7.7 (4.3–41.5)

<0.01

Serum TNF-α (pg/mL)

6.9 (0.7–14.7)

8.6 (7.3–15.4)

<0.01

  1. The data are the medians (ranges)
  2. aComparison between patients with and without cholestasis using Fisher’s exact test or the Mann–Whitney U test
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